In a large mixing bowl, combine high-quality ground beef with Worcestershire sauce, garlic powder, onion powder, salt, and black pepper. Mix until just combined and set aside.

Divide the beef mixture into equal portions and shape each into a patty about ¾ inch thick, making a slight indentation in the center.

Preheat your grill or skillet over medium-high heat until hot enough.

Cook the patties for 4-5 minutes on one side until browned, then flip and cook for another 4-5 minutes, aiming for an internal temperature of 160°F.

During the last minute of cooking, place a slice of cheddar cheese on top of each patty to melt.

Remove patties from heat, slice hamburger buns, spread creamy mayonnaise, and assemble the burgers with patties, lettuce, and tomato.

Serve immediately with your favorite sides.