In a mixing bowl, combine buttermilk with garlic powder, onion powder, paprika, salt, and black pepper. Add the chicken breasts to the marinade, ensuring they're well-coated. Cover and let marinate for at least 1 hour in the refrigerator.

Preheat your oven to 400°F (200°C). In a shallow dish, mix all-purpose flour, panko breadcrumbs, and grated Parmesan cheese.

Remove the chicken from the buttermilk and dredge each piece in the breadcrumb mixture, pressing lightly for an even coating.

Line a baking sheet with parchment paper. Arrange the breaded chicken pieces and bake for 20–25 minutes until golden brown and cooked through.

In a small mixing bowl, whisk together mayonnaise, lemon juice, and Worcestershire sauce until smooth. Adjust seasoning as needed.

Slice rolls in half, spread sauce on both sides, layer with lettuce and chicken, drizzle with Caesar dressing, and top with additional Parmesan.