Begin by bringing a large pot of salted water to a rolling boil. Add the elbow macaroni and cook according to package instructions until al dente, usually about 7-8 minutes. Once done, drain the pasta in a colander and set aside while you prepare the creamy cheese sauce.

In a medium saucepan over medium heat, melt 4 tablespoons of unsalted butter. Once melted, whisk in ¼ cup of all-purpose flour and cook for about 1-2 minutes until bubbly. Gradually pour in 3 cups of whole milk while continuously whisking to avoid lumps. Continue cooking until the mixture thickens, around 5-7 minutes, and resembles a smooth paste.

Reduce the heat to low and add 2 cups of grated sharp cheddar cheese, 1 cup of Monterey Jack, and ½ cup of grated Parmesan cheese to the thickened sauce. Stir until all the cheeses are fully melted and the sauce is creamy. Taste and season with salt and pepper as desired.

Carefully fold the cooked elbow macaroni into the creamy cheese sauce, ensuring each piece is well coated. Mix thoroughly for 2-3 minutes until the pasta and sauce are fully integrated.

Preheat your oven to 350°F (175°C). Pour the macaroni and cheese mixture into a greased 3-quart baking dish. In a small bowl, combine 1 cup of panko breadcrumbs with 2 tablespoons of melted butter, then sprinkle this mixture evenly over the mac and cheese.

Place the baking dish in the preheated oven for about 25-30 minutes, or until the top is golden brown and bubbly.