Bring a large pot of salted water to a rolling boil over high heat. Add 1 pound of elbow macaroni and cook until al dente, about 8-10 minutes. Drain and set aside.

In a saucepan, melt 4 tablespoons of unsalted butter over medium heat. Whisk in ¼ cup of all-purpose flour for about 1 minute, then gradually pour in 4 cups of whole milk while whisking continuously. Cook until thickened, about 5-7 minutes.

Reduce heat to low, stir in 2 cups of sharp cheddar, 1 cup of Monterey Jack, and ½ cup of Parmesan until fully melted. Season with salt and pepper.

Fold the drained macaroni into the cheese sauce, ensuring each piece is coated properly.

Preheat oven to 350°F (175°C). Transfer the mixture to a greased 3-quart baking dish. Mix 1 cup of panko breadcrumbs with 2 tablespoons of melted butter and sprinkle over the mac and cheese.

Bake uncovered for 25-30 minutes until the top is golden brown and bubbly. Let cool for about 5 minutes before serving.